MACROMOLECULAR DRUG CONJUGATES .5. THEOPHYLLINE-DEXTRAN

The paper discusses some alternative ways to the synthesis of theophyl line macromolecular conjugates, in which the drug is covalently linked , through a bridge to the dextran backbone. Theophylline-dextran conju gates may be obtained by two methods: (1) reaction of the drug with ch loroacetylated crosslinked dextran microparticles in organic basic apr otic solvents, and (2) reaction of 7-N-chloroacetyltheophylline with c rosslinked dextran microparticles in basic media. Release of theophyll ine from these two types of macromolecular conjugate was comparatively estimated.