Gliomatosis cerebri, a rare condition? requires clinical, radiological
and pathological correlation for diagnosis. Mental and personality ch
anges are the most common presenting symptoms with or without Focal ne
urological signs. The widespread nature of the disease is revealed by
CT or MRI. The shape of the brain may be: maintained and pathological
gross examination may be unremarkable or show hypertrophy without evid
ent tumour. Microscopic examination reveals infiltration of the brain
by variably differentiated neoplastic glial cells. We present a patien
t with gliomatosis cerebri in whom we experienced difficulties with di
agnosis. The literature is reviewed and the diagnostic features summar
ised.