L. Krishnaveni et Sn. Ghosh, IMPLICATION OF INVOLVEMENT OF RAT CHROMOSOME NUMBER-2 IN SPONTANEOUS TRANSFORMATION OF THE RAT-2 CELL-LINE, Cell biology international, 20(5), 1996, pp. 331-334
Using an in vitro model for cell transformation, the relationship betw
een specific chromosomal aberration and phenotypic changes was studied
at different passages of Rat-2 cell line. A marker chromosome resulti
ng from a translocation [t(2;7)] was found to be associated with focus
formation in soft agar. Conversely, the loss of this marker chromosom
e was found to be associated with phenotypic reversion. These results
suggest an association of this marker chromosome with phenotypic trans
formation for the Rat-cell line. (C) 1996 Academic Press Limited