IMPLICATION OF INVOLVEMENT OF RAT CHROMOSOME NUMBER-2 IN SPONTANEOUS TRANSFORMATION OF THE RAT-2 CELL-LINE

Authors
KRISHNAVENI L GHOSH SN
Citation
L. Krishnaveni et Sn. Ghosh, IMPLICATION OF INVOLVEMENT OF RAT CHROMOSOME NUMBER-2 IN SPONTANEOUS TRANSFORMATION OF THE RAT-2 CELL-LINE, Cell biology international, 20(5), 1996, pp. 331-334
Citations number
8
Categorie Soggetti
Cell Biology
Journal title
Cell biology international → ACNP
ISSN journal
10656995
Volume
20
Issue
5
Year of publication
1996
Pages
331 - 334
Database
ISI
SICI code
1065-6995(1996)20:5<331:IOIORC>2.0.ZU;2-W
Abstract
Using an in vitro model for cell transformation, the relationship betw een specific chromosomal aberration and phenotypic changes was studied at different passages of Rat-2 cell line. A marker chromosome resulti ng from a translocation [t(2;7)] was found to be associated with focus formation in soft agar. Conversely, the loss of this marker chromosom e was found to be associated with phenotypic reversion. These results suggest an association of this marker chromosome with phenotypic trans formation for the Rat-cell line. (C) 1996 Academic Press Limited