Perinatal asphyxia is increasingly recognized in equine neonatal units
. The incidence is hard to estimate because many foalings are unattend
ed and the disease is often complicated by other conditions. Perinatal
asphyxia is a significant cause of equine neonatal morbidity and mort
ality. The condition occurs in a wide variety of clinical settings tha
t result in decreased umbilical blood flow, uteroplacental perfusion,
or tissue oxygenation. Fetal factors, placental abnormalities, dystoci
a, or maternal illness can be involved. Associated fetal factors inclu
de twinning, congenital malformations of foals, and meconium aspiratio
n syndrome. Maternal factors that can be involved include conditions t
hat contribute to hypotension or impaired tissue oxygenation (e.g., en
dotoxemia, hemorrhage, anemia, or severe respiratory disease). Foals w
ith perinatal asphyxia are usually presented with weakness, mental dep
ression, decreased urine output, low blood pressure, and some degree o
f gastrointestinal disease. In affected foals, therapy should address
the multisystemic nature of the disease. High-quality nursing care is
essential and includes monitoring of blood gases, renal function, card
iac function, and nutritional status. Early recognition and aggressive
intervention are vital components of successful treatment.