DESIGN AND SYNTHESIS OF 2'-HYDROXYETHYLCYCLOPROPYL CARBOCYCLIC NUCLEOSIDES

Authors
YANG TF KIM H KOTRA LP CHU CK
Citation
Tf. Yang et al., DESIGN AND SYNTHESIS OF 2'-HYDROXYETHYLCYCLOPROPYL CARBOCYCLIC NUCLEOSIDES, Tetrahedron letters, 37(49), 1996, pp. 8849-8852
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
49
Year of publication
1996
Pages
8849 - 8852
Database
ISI
SICI code
0040-4039(1996)37:49<8849:DASO2C>2.0.ZU;2-Q
Abstract
The enantiomeric synthesis of beta-D-cyclopropyl carbocyclic nucleosid es was achieved via the key intermediate 5. Thymine and uracil derivat ives 7 and 9 were obtained by oxidation, Curtius rearrangement and the standard construction method of pyrimidines. The cytosine derivative 10 was prepared from 9 via the 4-triazole intermediate. Copyright (C) 1996 Elsevier Science Ltd.