A NEW MODEL FOR THE COENZYME B-12 CATALYZED METHYLMALONYL-SUCCINYL REARRANGEMENT INCORPORATING PERIPHERAL A-T BASE-PAIRING

Authors
DARBRE T KEESE R SILJEGOVIC V
Citation
T. Darbre et al., A NEW MODEL FOR THE COENZYME B-12 CATALYZED METHYLMALONYL-SUCCINYL REARRANGEMENT INCORPORATING PERIPHERAL A-T BASE-PAIRING, Chemical communications, (13), 1996, pp. 1561-1562
Citations number
22
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
13
Year of publication
1996
Pages
1561 - 1562
Database
ISI
SICI code
1359-7345(1996):13<1561:ANMFTC>2.0.ZU;2-A
Abstract
A novel B-12 derivative 4 containing a peripheral thymine group is alk ylated under reductive conditions with 2-bromo- methyl-2-methylmonothi omalonate 8 bearing the complementary adenine; photolysis in chlorofor m-acetonitrile gives the rearranged succinate 12 and dimethylmalonate 13 (2:1), whereas in MeOH-H2O only the dimethylmalonate 13 is formed.