TREATMENT OF MIXED CRYOGLOBULINEMIA WITH RECOMBINANT INTERFERON-ALPHAAND ADJUVANT THERAPIES - A PROSPECTIVE-STUDY ON 20 PATIENTS

Authors
COHEN P NGUYEN QT DENY P FERRIERE F ROULOT D LORTHOLARY O JARROUSSE B DANON F BARRIER JH CECCALDI J CONSTANS J CRICKX B FIESSINGER JN HACHULLA E JACCARD A SELIGMANN M KAZATCHKINE M LAROCHE L SUBRA JF TURLURE P GUILLEVIN L
Citation
P. Cohen et al., TREATMENT OF MIXED CRYOGLOBULINEMIA WITH RECOMBINANT INTERFERON-ALPHAAND ADJUVANT THERAPIES - A PROSPECTIVE-STUDY ON 20 PATIENTS, Annales de medecine interne, 147(2), 1996, pp. 81-86
Citations number
16
Categorie Soggetti
Medicine, General & Internal
Journal title
Annales de medecine interne → ACNP
ISSN journal
0003410X
Volume
147
Issue
2
Year of publication
1996
Pages
81 - 86
Database
ISI
SICI code
0003-410X(1996)147:2<81:TOMCWR>2.0.ZU;2-R
Abstract
In order to evaluate the efficacy of interferon alpha (IFNa) in mixed cryoglobulinemia (MC), a prospective multicenter clinical trial was co nduced in April 1992. It consisted of treating 20 clinically symptomat ic MC patients with IFNa fot 26 weeks. Hepatitis C virus (HCV) infecti on was detected in 16 patients. A complete or partial clinical remissi on was obtained in 12 patients (60%). Eleven of these 12 responders (9 1.6%) experienced a clinical relapse less than 12 months after the end of therapy, Side effects were noted in 10 patients (50%). It was conc luded that subcutaneously administered IFNa does not provide long-term remission.