GIANT T-WAVE INVERSION ASSOCIATED WITH SEVERE AORTIC REGURGITATION

Two patients with haemodynamically significant aortic regurgitation an d angiographically normal coronary arteries developed giant T wave inv ersion. The T wave abnormality partially resolved in both; following v alve replacement in one and medical treatment in the other. This unusu al electrocardiographic appearance may be related to myocardial ischae mia caused by increased left ventricular wall stress and changes in ph asic coronary blood flow, abnormalities in cerebral perfusion associat ed with severe aortic regurgitation, or to coincidental neurological d isease.