M. Ducher et al., SPONTANEOUS CARDIAC BARORECEPTOR REFLEX AND REGIONAL CIRCULATIONS IN CONSCIOUS RATS, Journal of hypertension, 14(7), 1996, pp. 865-869
Objective To determine the relationships between the activity of the s
pontaneous cardiac baroreceptor reflex (BRX) and regional vascular dyn
amics in conscious unrestrained rats. Design Simultaneous beat-to-beat
recordings of blood pressure and measurements of indices of mesenteri
c and hindquarters blood flows were performed in seven male normotensi
ve conscious rats under baseline conditions during 1 h. Methods The re
lationships between systolic blood pressure (SBP) and heart rate were
examined using a computerized method, giving the degree of statistical
dependence between values of the two parameters with the Z coefficien
t, This analysis permitted detection of cardiac beats related to cardi
ac BRX activity, Z analysis was also applied to SBP and to mesenteric
or hindquarters blood flow or vascular resistance, Time-series represe
ntations were used to describe the chronological patterns correspondin
g to BRX spontaneous activity. Results In these rats, which presented
spontaneous BRX-like patterns manifested by the Z analysis, BRX was ac
tive during approximately 15% of the time, For 80% of these patterns,
cardiac BRX acted to buffer falls in SBP. These depressor events were
preceded by muscular vasodilations whereas vasodilations in the mesent
ery were delayed, Z analysis of these spontaneous haemodynamic pattern
s confirmed that muscular vasodilations were strongly associated with
falls in SBP, whereas vasodilations lagged behind SBP by about seven b
eats and were not dependent on simultaneous SBP values. Conclusions Th
e Z method showed that spontaneous hindquarters vasodilations were ass
ociated with cardiac BRX patterns and that mesenteric vasodilations we
re not concomitant with falls in SBP and may be the consequence either
of a delayed central response or of a local mechanism such as myogeni
c autoregulation.