THE EFFECTS OF DIALYZER REUSE ON PLASMA ANTIOXIDATIVE MECHANISMS IN PATIENTS ON REGULAR HEMODIALYSIS-TREATMENT

The effects of antioxidative mechanism are known to be reduced in pati ents on regular hemodialysis treatment (RHT). The data about the effec ts of reuse on antioxidative mechanisms are limited. Twelve patients o n RHT (age range: 16-50 years) were included in the study. The basal a nd after 4 months of dialyzer reuse period, plasma antioxidant activit y (AOA), myeloperoxidase (MPO) activity, ceruloplasmin (Cp), copper (C u), transferrin (TF), and sulphydryl group (SH) levels were detected. The basal plasma AOA (110.92 +/- 17.19 mu l), TF (1.23 +/- 0.23 g/l), and SH (307.11 +/- 51.81 mu mol/l) levels were lower than the levels o f the control subjects (73.75 +/- 9.07 mu l, 2.38 +/- 0.25 g/l, 690.59 +/- 84.18 mu mol/l) (p < .001). The basal Cp (0.47 +/- 0.08 g/l) and MPO activity (86.31 +/- 9.57 U/l) levels were higher than the levels o f the control subjects (0.34 +/- 0.07 g/l and 65.90 +/- 7.28 Un) (p < .001). The basal Cu levels (1.19 +/- 0.24 mg/l) were similar to the le vels of the control subjects (1.11 +/- 0.13 mg/l) (p > .05). The diffe rence between plasma AOA (83.33 +/- 14.71 mu l), Cp (0.38 +/- 0.08 g/l ), and MPO activity (64.43 +/- 10.01 U/l) after the reuse period and t he control values were not statistically significant (p > .05). The TF (1.87 +/- 0.15 g/l) levels after the reuse period were significantly lower than the control values (p < .001), although the levels were inc reased after the reuse period. Our findings may indicate some benefici al effects of hemodialyzer reuse process on plasma antioxidative mecha nisms in patients on RHT.