KIT PREPARATION OF SM-153-EDTMP AND FACTORS AFFECTING RADIOCHEMICAL PURITY AND STABILITY

Authors
FERROFLORES G TENDILLA JI LOPEZGOMEZ MA GONZALEZZAVALA MA PARADESGUTIERREZ L AVILARAMIREZ E AGUILARHERNANDEZ F
Citation
G. Ferroflores et al., KIT PREPARATION OF SM-153-EDTMP AND FACTORS AFFECTING RADIOCHEMICAL PURITY AND STABILITY, Journal of radioanalytical and nuclear chemistry, 204(2), 1996, pp. 303-311
Citations number
5
Categorie Soggetti
Chemistry Analytical","Nuclear Sciences & Tecnology","Chemistry Inorganic & Nuclear
Journal title
Journal of radioanalytical and nuclear chemistry → ACNP
ISSN journal
02365731
Volume
204
Issue
2
Year of publication
1996
Pages
303 - 311
Database
ISI
SICI code
0236-5731(1996)204:2<303:KPOSAF>2.0.ZU;2-Y
Abstract
A fast kit method was developed for the production of Sm-153-EDTMP in two steps avoiding the use of nitric acid, evaporation and sterilizati on of the final solution by autoclave. Methods of analysis for the det ermination of chemical and radiochemical purity in the radiopharmaceut ical solution were established. Factors affecting radiochemical purity and stability of the complex as the molar ratio of EDTMP/Sm, concentr ation of phosphate buffer and neutralization of EDTMP prior kit prepar ation were also analyzed. The use of this radiopharmaceutical in rabbi ts and patients showed selective skeletal uptake.