CONFORMATIONALLY CONSTRAINED TRYPTOPHAN ANALOGS - SYNTHESIS OF (+ )-(Z)-2-AMINO-2,3-METHANO-3-(INDOL-3-YL)-PROPANOIC AND )-(E)-2-AMINO-2,3-METHANO-3-(INDOL-3-YL)-PROPANOIC ACIDS/

Citation
D. Donati et al., CONFORMATIONALLY CONSTRAINED TRYPTOPHAN ANALOGS - SYNTHESIS OF (+ )-(Z)-2-AMINO-2,3-METHANO-3-(INDOL-3-YL)-PROPANOIC AND )-(E)-2-AMINO-2,3-METHANO-3-(INDOL-3-YL)-PROPANOIC ACIDS/, Tetrahedron, 52(29), 1996, pp. 9901-9908
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404020
Volume
52
Issue
29
Year of publication
1996
Pages
9901 - 9908
Database
ISI
SICI code
0040-4020(1996)52:29<9901:CCTA-S>2.0.ZU;2-9
Abstract
The syntheses of (+/-)-(Z)- and )-(E)-2-amino-2,3-methano-3-(indol-3-y l)-propanoic acids (8 and 15) are reported. Key step in their preparat ion is the cyclopropanation of an olefinic azlactone derivative, follo wed by a suitable deprotection sequence. Copyright (C) 1996 Elsevier S cience Ltd