NOT ALL SHCS ROADS LEAD TO RAS

The She proteins have been implicated in the Ras signaling pathway by virtue of their association with the Grb2 adaptor molecule. Several li nes of evidence indicate that this association is indeed involved in R as activation. More recent experiments in mammalian tissue culture cel ls suggest that domains unique to She isoforms, named CH1 and CH2, mig ht be involved in a new network of protein-protein interactions, and h int at other roles that She might play in addition to Ras activation.