Cs. Cooper et al., THE EFFECT OF EXOGENOUS TESTOSTERONE ON TOTAL AND FREE PROSTATE-SPECIFIC ANTIGEN LEVELS IN HEALTHY-YOUNG MEN, The Journal of urology, 156(2), 1996, pp. 438-441
Purpose: We evaluated the effect of exogenous testosterone administrat
ion on serum total and free prostate specific antigen (PSA) in healthy
young men. Materials and Methods: Nine volunteers received either 100
, 250 or 500 mg, testosterone by intramuscular injection each week for
15 weeks. Blood was drawn every other week for 28 weeks and at week 4
0. Serum total and free PSA, and total and free testosterone were meas
ured and compared to baseline values. Results: Significant elevations
in total and free testosterone occurred but no significant change in s
erum total and free PSA was detected. Conclusions: Serum PSA is not re
sponsive to elevated serum testosterone levels in healthy young men. P
SA metabolism in the normal prostate is unclear but our findings may h
ave implications for differentiation of pathological conditions of the
human prostate.