Depression is a common but highly treatable mood disorder. Unfortunate
ly, two thirds of depressed patients may never receive appropriate int
ervention. Because of individual and societal barriers to the diagnosi
s, depressive symptoms often go unrecognized. However, primary care ph
ysicians are in a unique position to surmount these obstacles by being
alert to manifestations of the disorder. Treatment with antidepressan
t drugs, psycho-therapy, electroconvulsive therapy, or a combination o
f these is very efficacious. The choice of method is based on such fac
tors as history of previous response, severity of disease, concomitant
medical illness, and patient preference.