ABNORMAL UTERINE BLEEDING WITH NORMAL UTERINE FLUID LEVEL OF HUMAN DECIDUA-ASSOCIATED PROTEIN-200 REFLECTS NORMAL ENDOMETRIAL HISTOLOGY

In the current study, the uterine fluid level of human decidua-associa ted protein (hDP) 200 was measured in 80 women with abnormal uterine b leeding and normal histology. In 20 women the level of hDP200 was also correlated with the endometrial thickness measured by transvaginal ul trasonography. The results demonstrated the same distribution and simi lar levels of uterine fluid hDP200 throughout the menstrual cycle as i n regularly cycling women, with no correlation between the levels of h DP200 and the endometrial thickness. Thus, the test for uterine fluid hDP200 could serve to discriminate between benign and pathological exa minations of endometrial biopsies in women of reproductive age, women with abnormal uterine bleeding and benign conditions of the endometriu m. Very low levels of hDP200 are indicative of endometrial hyperplasia or carcinoma.