APPLICATION OF CEFQUINOME IN CATTLE - CON CENTRATION VS TIME IN BRONCHIAL-SECRETIONS AND IN-VITRO ACTIVITY AGAINST PASTEURELLA SPP

From pharmacokinetic data (C-max, T-max, AUC(0.24h)) and a comparison of the availability of cefquinome in bronchial secretions (BS) with th e in vitro activity against bovine field strains of P. haemolytica und P. multocida the suitability of cefquinome in the treatment of respir atory disease in cattle has been demonstrated. Regarding the period be tween 1994 and 1996, the MIC(50%) and MIC(90%) values were 0.03 and 0. 06 mu g/ml for P. haemolytica (n = 107), and 0.03 and 0.5 mu g/ml for P. multocida (n = 117), respectively. Consequently, cefquinome concent rations which are reached in bronchial secretions during the first 24 hours after 24 hours after application of 1.0 mg/kg b.w. and which amo unt to C-max BS = 2.17 mu g/ml or at least 0.59 mu g/ml after 24 hours always exceed MIC values of the Pasteurella species. The favourable s usceptibility data of P. haemolytica adn P. multocida from 1990 to 199 3 has been confirmed by isolates from 1994 to 1996. P. haemolytica iso lates of the recent period have shown no resistance, and incidence of resistance of P. multocida was below 1%.