SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A SERIES OF ISOINDOLONE DERIVATIVES RELATED TO CYTOCHALASINS

Authors
PISTELLI L BENASSI S MIGLIORE L PAPA S ANDREASSI MG
Citation
L. Pistelli et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A SERIES OF ISOINDOLONE DERIVATIVES RELATED TO CYTOCHALASINS, Il Farmaco, 51(6), 1996, pp. 401-406
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
6
Year of publication
1996
Pages
401 - 406
Database
ISI
SICI code
0014-827X(1996)51:6<401:SABOAS>2.0.ZU;2-P
Abstract
A series of hydrogenated isoindolone derivatives structurally related to cytochalasin B has been synthesized and their ability to induce bin ucleation in the human lymphocytes were tested. All compounds were fou nd able to inhibit cell cytokinesis at different extent in the range ( 3.12-25 mu mol/l) respect to the negative control; however the highest percentage of binucleated cells is induced by Cyt B.