SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW PIPERIDINYL BENZIMIDAZOLES

Authors
KUS C GOKER H AYHAN G ERTAN R ALTANLAR N AKIN A
Citation
C. Kus et al., SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW PIPERIDINYL BENZIMIDAZOLES, Il Farmaco, 51(6), 1996, pp. 413-417
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
6
Year of publication
1996
Pages
413 - 417
Database
ISI
SICI code
0014-827X(1996)51:6<413:SAAAOS>2.0.ZU;2-C
Abstract
A series of ridin-1-yl)-1,5(6)-disubstituted-1H-benzimidazoles (1-18) were prepared through the reaction of 2-chloro (or 2-chloromethyl)-1H- benzimidazole derivatives with 4-methylpiperidine. For the preparation of the individual isomers, compounds 7, 9 and 18 were synthesized by a multistep procedure. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compound 3 and 4 exh ibited the best antifungal activity.