CHRONIC OBSTRUCTIVE BRONCHITIS - SOME PAT HOGENETIC ASPECTS AND SPECIFIC CLINICAL-FEATURES

Lipid peroxidation (LPO) and antioxidant system (AOS) were examined in 40 inpatients with chronic obstructive bronchitis (COB) on convention al treatment. The above parameters were considered in relation to clin ical picture. It is shown that inflammation in the bronchial tree is a ssociated with AOS functional deterioration and marked LPO intensifica tion. A correlation was established between LPO activity, concentratio n of alpha-tocopherol in red cell membrane and degree of bronchial obs truction as well as remission quality. Persistent high intensity of LP O is suggested as an underlying cause of the disease transition to chr onic form and progression of bronchial obstruction. Basing on the abov e observations, the authors insist on antioxidants introduction in COB treatment.