PATHOPHYSIOLOGICAL MECHANISMS OF BRONCHIA L OBSTRUCTION - SOME DIAGNOSTIC-TECHNIQUES

Citation
Ag. Kuznetsova et al., PATHOPHYSIOLOGICAL MECHANISMS OF BRONCHIA L OBSTRUCTION - SOME DIAGNOSTIC-TECHNIQUES, Terapevticeskij arhiv, 68(3), 1996, pp. 62-65
Citations number
7
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
00403660
Volume
68
Issue
3
Year of publication
1996
Pages
62 - 65
Database
ISI
SICI code
0040-3660(1996)68:3<62:PMOBLO>2.0.ZU;2-C
Abstract
Lipid peroxidation (LPO) and antioxidant system (AOS) were examined in 40 inpatients with chronic obstructive bronchitis (COB) on convention al treatment. The above parameters were considered in relation to clin ical picture. It is shown that inflammation in the bronchial tree is a ssociated with AOS functional deterioration and marked LPO intensifica tion. A correlation was established between LPO activity, concentratio n of alpha-tocopherol in red cell membrane and degree of bronchial obs truction as well as remission quality. Persistent high intensity of LP O is suggested as an underlying cause of the disease transition to chr onic form and progression of bronchial obstruction. Basing on the abov e observations, the authors insist on antioxidants introduction in COB treatment.