Ag. Kuznetsova et al., PATHOPHYSIOLOGICAL MECHANISMS OF BRONCHIA L OBSTRUCTION - SOME DIAGNOSTIC-TECHNIQUES, Terapevticeskij arhiv, 68(3), 1996, pp. 62-65
Lipid peroxidation (LPO) and antioxidant system (AOS) were examined in
40 inpatients with chronic obstructive bronchitis (COB) on convention
al treatment. The above parameters were considered in relation to clin
ical picture. It is shown that inflammation in the bronchial tree is a
ssociated with AOS functional deterioration and marked LPO intensifica
tion. A correlation was established between LPO activity, concentratio
n of alpha-tocopherol in red cell membrane and degree of bronchial obs
truction as well as remission quality. Persistent high intensity of LP
O is suggested as an underlying cause of the disease transition to chr
onic form and progression of bronchial obstruction. Basing on the abov
e observations, the authors insist on antioxidants introduction in COB
treatment.