CLASSIFICATION OF CSF SAMPLES FROM NORMAL AND POSTPARTUM PSYCHOTIC WOMEN USING CHROMATOGRAPHIC PROFILES WITH BILINEAR PROJECTIONS - A MULTIVARIATE APPROACH

This paper demonstrates how chromatographic profiles of cerebrospinal fluid (CSF) have been subjected to multivariate data analysis to discr iminate between CSF samples from women with post-partum psychosis and those from healthy women, Instead of peak-heights or areas, digitally defined chromatographic profiles were examined using principal compone nt analysis (PCA), In accordance with the diagnosis, we have found a c omplex profile pattern of at least ten composite peaks that discrimina tes between these groups. Two of these peaks were for the discriminati on particularly clearly between the two groups, We speculate that thes e findings can be useful in the diagnosis of post-partum psychosis, in creasing diagnostic precision and having both clinical and prognostic implications.