STUDY ON THE DETERMINATION OF CLOZAPINE BY VOLTAMMETRY

Authors
OZKAN SA SENTURK Z
Citation
Sa. Ozkan et Z. Senturk, STUDY ON THE DETERMINATION OF CLOZAPINE BY VOLTAMMETRY, Analusis, 24(3), 1996, pp. 73-75
Citations number
20
Categorie Soggetti
Chemistry Analytical
Journal title
Analusis → ACNP
ISSN journal
03654877
Volume
24
Issue
3
Year of publication
1996
Pages
73 - 75
Database
ISI
SICI code
0365-4877(1996)24:3<73:SOTDOC>2.0.ZU;2-V
Abstract
The oxidative behavior of clozapine was studied as a function of PH at a glassy carbon electrode activated by applying a new pretreatment. T he oxidation process was shown to be irreversible. The characteristics of the corresponding electrode reaction were discussed. A voltammetri c method was developed at pH 4.5 (acetate buffer) for the quantitative determination of clozapine. The peak current was linear with the cloz apine concentration in the range 2 10(-6) M-8 10(-4) M. The method was applied to the assay of clozapine tablets.