INHIBITORY EFFECT OF TARAXASTANE-TYPE TRITERPENES ON TUMOR PROMOTION BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN 2-STAGE CARCINOGENESIS IN MOUSE SKIN

Authors
YASUKAWA K AKIHISA T OINUMA H KAMINAGA T KANNO H KASAHARA Y TAMURA T KUMAKI K YAMANOUCHI S TAKIDO M
Citation
K. Yasukawa et al., INHIBITORY EFFECT OF TARAXASTANE-TYPE TRITERPENES ON TUMOR PROMOTION BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN 2-STAGE CARCINOGENESIS IN MOUSE SKIN, Oncology, 53(4), 1996, pp. 341-344
Citations number
22
Categorie Soggetti
Oncology
Journal title
Oncology → ACNP
ISSN journal
00302414
Volume
53
Issue
4
Year of publication
1996
Pages
341 - 344
Database
ISI
SICI code
0030-2414(1996)53:4<341:IEOTTO>2.0.ZU;2-D
Abstract
Two taraxastane-type hydroxy triterpenes, taraxasterol and faradiol, i solated from the flowers of Compositae plants Cynara scolymus (articho ke) and Chrysanthemum morifilolium (chrysanthemum), respectively, show ed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-ace tate (TPA)-induced inflammation in mice. At 2.0 mu mol/mouse, these co mpounds inhibited markedly the tumor-promoting effect of TPA (1 mu g/m ouse) on skin tumor formation following initiation with 7,12-dimethylb enz[a]anthracene (50 mu g/mouse).