AP1 ENHANCES POLYOMAVIRUS DNA-REPLICATION BY PROMOTING T-ANTIGEN-MEDIATED UNWINDING OF DNA

Authors
GUO WD TANG WJ BU XX BERMUDEZ V MARTIN M FOLK WR
Citation
Wd. Guo et al., AP1 ENHANCES POLYOMAVIRUS DNA-REPLICATION BY PROMOTING T-ANTIGEN-MEDIATED UNWINDING OF DNA, Journal of virology, 70(8), 1996, pp. 4914-4918
Citations number
62
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
70
Issue
8
Year of publication
1996
Pages
4914 - 4918
Database
ISI
SICI code
0022-538X(1996)70:8<4914:AEPDBP>2.0.ZU;2-Z
Abstract
An early step in the initiation of polyomavirus DNA replication is vir al large-T-antigen mediated unwinding of the origin. We report that co mponents of the AP1 transcription factor, Fos and Jun, interact with T antigen in vitro to enhance unwinding of the viral origin. This provi des a biochemical basis for the capacity of AP1 to activate viral DNA replication in vivo.