NEUTRALIZING ANTIBODIES TO DIFFERENT PROTEINS OF AFRICAN SWINE FEVER VIRUS INHIBIT BOTH VIRUS ATTACHMENT AND INTERNALIZATION

Authors
GOMEZPUERTAS P RODRIGUEZ F OVIEDO JM RAMIROIBANEZ F RUIZGONZALVO F ALONSO C ESCRIBANO JM
Citation
P. Gomezpuertas et al., NEUTRALIZING ANTIBODIES TO DIFFERENT PROTEINS OF AFRICAN SWINE FEVER VIRUS INHIBIT BOTH VIRUS ATTACHMENT AND INTERNALIZATION, Journal of virology, 70(8), 1996, pp. 5689-5694
Citations number
34
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
70
Issue
8
Year of publication
1996
Pages
5689 - 5694
Database
ISI
SICI code
0022-538X(1996)70:8<5689:NATDPO>2.0.ZU;2-U
Abstract
African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analys is of the neutralization mechanisms mediated by the different viral pr oteins showed that antibodies to proteins p72 and p54 are involved in the inhibition of a first step of the replication cycle related to vir us attachment, while antibodies to protein p30 are implicated in the i nhibition of virus internalization.