EVIDENCE FOR A PHOSPHORYLATION SITE IN CYTOMEGALOVIRUS GLYCOPROTEIN GB

Authors
NORAIS N HALL JA GROSS L TANG DZ KAUR S CHAMBERLAIN SH BURKE RL MARCUS F
Citation
N. Norais et al., EVIDENCE FOR A PHOSPHORYLATION SITE IN CYTOMEGALOVIRUS GLYCOPROTEIN GB, Journal of virology, 70(8), 1996, pp. 5716-5719
Citations number
23
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
70
Issue
8
Year of publication
1996
Pages
5716 - 5719
Database
ISI
SICI code
0022-538X(1996)70:8<5716:EFAPSI>2.0.ZU;2-8
Abstract
As part of our vaccine program, we have purified a recombinant form of human cytomegalovirus glycoprotein B that is able to induce high tite rs of virus-neutralizing antibodies. The isolated protein was found to be phosphorylated at a serine residue in position -7 from the C termi nus of the protein. The corresponding synthetic peptide, HLKDSDEEENV, was an efficient in vitro substrate of casein kinase II.