POLYMERASE CHAIN-REACTION ANALYSIS OF ALLELE POLYMORPHISM OF 2 HYPERVARIABLE LOCI IN A MOSCOW RUSSIAN POPULATION-SAMPLE

PCR analysis of the allele polymorphism of two hypervariable loci D1S1 11 and RB1-VNTR among 120 unrelated Russians living in Moscow revealed 14 alleles of D1S111 381-861 bp long and 9 alleles of RE I-VNTR 1200- 1650 bp long. One of the D1S111 alleles was sequenced, thus permitting allele classification according to the number of tandem repeats. For both loci the observed genotype frequencies were shown to correspond t o the Hardy-Weinberg equilibrium. The allele frequency distribution wa s compared in the Russian and American population samples. These polym orphic loci are proposed for individual identity and paternity tests.