IMPROVEMENT OF THE KIRROMYCIN FERMENTATION BY RESIN ADDITION

Authors
GASTALDO L MARINELLI F ACQUARELLA C RESTELLI E QUARTA C
Citation
L. Gastaldo et al., IMPROVEMENT OF THE KIRROMYCIN FERMENTATION BY RESIN ADDITION, Journal of industrial microbiology, 16(5), 1996, pp. 305-308
Citations number
18
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Journal of industrial microbiology → ACNP
ISSN journal
01694146
Volume
16
Issue
5
Year of publication
1996
Pages
305 - 308
Database
ISI
SICI code
0169-4146(1996)16:5<305:IOTKFB>2.0.ZU;2-R
Abstract
The kirromycin yield of Actinoplanes sp A8924 was improved from 30-50 mg L(-1) to 350 mg L(-1) by mutant selection and medium optimization, The incorporation of polystyrenic resins into the fermentations promot ed a further fourfold enhancement of kirromycin productivity to 1500 m g L(-1). The positive effect of resin addition appears to be due to re moval of kirromycin from the fermentation broth because kirromycin's m inimal inhibitory concentration against the producing strain remained at ca 350 mg L(-1).