COMPLEMENT-4 LOCUS-II GENE DELETION AND DQA1-ASTERISK-0301 GENE - GENETIC RISK-FACTORS FOR IGA NEPHROPATHY AND HENOCH-SCHONLEIN NEPHRITIS

There have been several reports suggesting that the deficiency of comp lement 4 (C4) and/or deletion of C4 genes are the genetic risk factors in patients with IgA nephropathy (IgAN) and Henoch-Schonlein nephriti s (HSN). In the current study, we tried to clarify the genetic structu re of deleted C4 genes as well as the isotype deficiency of the patien ts. Also, we investigated the DQB and DRB genes which are located near the C4 genes to identify a possible linkage and to find the associate d allele, Our results showed that locus II deletion of C4, not the C4B sequence loss, is a risk factor for these diseases and the deleted ge ne can be either C4A or C4B, There was no specific isotype deficiency or specific allotype which was significantly increased or decreased in the patients. But, there was an increased frequency of DQA10301 gene in the patient group (corrected p = 0.04), which suggests that DQA10 301 as well as C4 gene deletion could be genetic risk factors for thes e diseases.