The improvement in the knowledge of the main anatomical landmarks perm
its an evolution in the safety of the surgical treatment and a concept
ual development of the geometrical anatomico-surgical characteristics
of the infratemporal fossa. This conceptual evolution determines surgi
cal and oncological advantages: firstly, improved comprehension of the
anatomico-surgical limits of the resection and secondly the safeguard
ing of the oncological ''en-bloc'' dissection. The lateral approach of
the infratemporal fossa gives a wider exposure of the surgical field,
a shorter depth of work, a good control over the vessels and the poss
ibility of carry out a microsurgical transfer. The surgical approaches
correspond to the topographical location and the biology of the neopl
asm in cases with infratemporal fossa and inferior compartment locatio
n the lateral transfacial approach is indicated. In cases with involve
ment of the superior compartment a lateral transcraniofacial subtempor
al approach is necessary in order to remove the skull base. In cases w
ith a neoplastic invasion of the skull base where the dura mater is th
e anatomical plane free from disease it is necessary to utilize an int
radural approach, In patients with a secondary spread into the inferio
r compartment from the maxilla a combined antero-lateral transfacial a
pproach is indicated. Finally, an orbitomaxillary involvement with sec
ondary spread in the upper compartment of the infratemporal fossa nece
ssitates an antero-lateral transcraniofacial subtemporal subfrontal ap
proach.