GANGLIOSIDES MODULATE THE GROWTH-RATE AND CELL PHENOTYPE OF A MURINE PRIMITIVE NEURO-ECTODERMAL TUMOR

Intratumoural administration of gangliosides (GSD) into a murine primi tive neuro-ectodermal tumour, growing in the epicranial subcutaneous t issue of syngenic rats, results in a decrease in the tumour growth rat e and causes a more differentiated phenotype of tumour cell, with immu nohistochemical expression of neuronal markers. These findings suggest that the potential usefulness of intralesional administration of GSD for the control of tumours of primitive neuro-epithelial character cou ld be considered.