LACK OF ASSOCIATION BETWEEN AUGMENTATION MAMMAPLASTY AND SYSTEMIC-SCLEROSIS (SCLERODERMA)

Objective. To examine the possible association between augmentation ma mmoplasty and systemic sclerosis (SSc; scleroderma). Methods. Eight hu ndred thirty-seven women with a clinical diagnosis of SSc, recruited a s a volunteer sample from 3 university-based, tertiary care scleroderm a clinical research centers, and 2,507 race-matched local control wome n, recruited by the technique of random-digit-dialing and frequency-ma tched on age, completed a questionnaire providing data on history of a ugmentation mammoplasty, including possible complications of the proce dure. The odds ratio (OR) and 95 percent confidence interval (95% CI) for the association of augmentation mammoplasty with SSc were estimate d by multivariate logistic regression analysis with adjustment for age , race and center, and by conditional logistic regression analysis wit h adjustment for age. Results. Eleven (1.31%) of the 837 cases reporte d a history of augmentation mammoplasty prior to diagnosis of SSc, com pared with 31 (1.24%) of the 2,507 controls. The adjusted OR from the unmatched analysis was 1.07 (95% CI 0.53-2.13), while that from the ma tched analysis was 1.11 (95% CI 0.55-2.24). Conclusion. These results fail to demonstrate a significant association between augmentation mam moplasty and SSc, and are consistent with those reported from other ep idemiologic studies.