PROGRESSION OF RHEUMATOID-ARTHRITIS FOLLOWING BONE-MARROW TRANSPLANTATION - A CASE-REPORT WITH A 13-YEAR FOLLOW-UP

Authors
MCKENDRY RJR HUEBSCH L LECLAIR B
Citation
Rjr. Mckendry et al., PROGRESSION OF RHEUMATOID-ARTHRITIS FOLLOWING BONE-MARROW TRANSPLANTATION - A CASE-REPORT WITH A 13-YEAR FOLLOW-UP, Arthritis and rheumatism, 39(7), 1996, pp. 1246-1253
Citations number
21
Categorie Soggetti
Rheumatology
Journal title
Arthritis and rheumatism → ACNP
ISSN journal
00043591
Volume
39
Issue
7
Year of publication
1996
Pages
1246 - 1253
Database
ISI
SICI code
0004-3591(1996)39:7<1246:PORFBT>2.0.ZU;2-D
Abstract
The progression of rheumatoid arthritis (RA) is documented in a patien t receiving a sex-mismatched, allogeneic bone marrow transplant (BMT) for gold-induced marrow aplasia. DNA typing confirmed a high probabili ty of a full donor engraftment (complete chimerism). Although the RA w as in complete remission 2 years post-BMT, clinical, laboratory, histo logic, and radiologic evidence of the recurrence of synovitis from 3-1 3 years post-BMT is presented, Implications of these observations for theories of the pathogenesis of RA and the future of immunotherapies a re discussed.