CONSOLIDATION AND RETRIEVAL OF HALOPERIDO L CATALEPSY STATE

Catalepsy induced by a single intraperitoneal injection of haloperidol (2.5 mg/kg) was consolidated and without additional influences and re tained within 2 weeks (being tested on the 2nd, 7th, and 14th days aft er injection). Enhancement of catalepsy retrieval was observed during testing of the same animals on the 14th day as compared with the 7th d ay. Maximal catalepsy expression was reached after 2 hours of testing procedure which points to the existence of the mechanism of autoenhanc ement of retrieval which is probably underlied by the automodulation o f the long-lasting modulatory DA receptors. The retrieval of catalepsy is suggested to be induced by a situational conditioned stimulus, sin ce on the 2nd, 7th and 14th days it may be reproduced without repeated haloperidol injection only in the testing box.