DRUG-INDUCED TRANSIENT MYOPIA AND ANGLE-CLOSURE GLAUCOMA ASSOCIATED WITH SUPRACILIARY CHOROIDAL EFFUSION

PURPOSE: We investigated the mechanism of drug-induced transient myopi a, anterior chamber shallowing, and secondary angle-closure glaucoma i n a young woman.METHODS: Ultrasound biomicroscopy was performed and th e effects of cycloplegic eyedrops and unilateral laser iridotomy were evaluated. RESULTS: Cycloplegic eyedrops and unilateral laser iridotom y had no effect, Ultrasound biomicroscopy identified the presence of a supraciliary choroidal effusion that caused forward displacement of t he lens-iris diaphragm, resulting in increased myopia, anterior chambe r shallowing, and angle-closure glaucoma. Discontinuance of trimethopr im and sulfamethoxazole combination led to the complete resolution of the condition. CONCLUSIONS: Idiosyncratic drug reactions may produce a supraciliary choroidal effusion, resulting in myopia and secondary an gle-closure glaucoma from the induced forward shift in the position of the crystalline lens and ciliary body.