LIPOSOMAL TARGETING AND DRUG-DELIVERY - KINETIC CONSIDERATION

As drug carriers, liposomes have great potential in that selective tar geting and release rate control of drugs can be performed by appropria te modifications to the carrier itself, without altering the structure of original drugs. In this paper, factors determining the disposition of liposomes were discussed in relation to the underlying mechanisms. Selective targetings of liposomes to specific tissues such as hepatoc ytes, macrophages and tumors were also evaluated based on the in vitro as well as in vivo data. Finally, the perspective of intracellular dr ug delivery was also discussed from the mechanistic as well as kinetic points of view for the development of intracellular targetable drug c arriers.