Np. Kuznetsova et al., INCREASE IN THE OXYGEN-TRANSPORT EFFICIENCY OF HEMOGLOBIN DURING ITS CHEMICAL MODIFICATION, Biochemistry, 61(4), 1996, pp. 495-501
Polycondensation of human hemoglobin with glutaric dialdehyde premodif
ied by acid group containing reagents (glutamic acid or sodium bisulfi
te) has been performed. The cross-linked polyhemoglobin shows the bett
er oxygen-transport properties than the native hemoglobin.