Objective: To critically review the elements of laboratory services th
at result in inappropriate ordering of clinical chemistry tests and th
e efficacy of corrective interventions. Methods and Results: In our ex
perience, inappropriate use of laboratory services derives from multip
le factors, including the use of multitest profiles, organ- or disease
-specific test panels, indiscriminate ordering, standing orders, exces
sive reporting delays, poor audit trails of test requests, rigid group
test ordering, failure to eliminate obsolete tests, and some features
of computer software design. Educational strategies can be effective
in modifying test-ordering patterns, provided there is sustained feedb
ack to physicians. Careful design of requisitions and the use of disea
se-specific algorithms have also proven effective. Conclusion: Limited
resources must be directed to where they are most effective by optimi
zing laboratory work-flow from test ordering to reporting, to avoid pr
actices that promote inappropriate laboratory use.