EFFECT OF HEREDITARY FACTORS ON TOLERANCE FOR SURGICAL-TREATMENT IN PATIENTS WITH PULMONARY-CANCER

Genetic polymorphism at 10 independent loci (ABO, RH, HP GC, PI, TF, A CP1, PGM1, GLO1, and PTC) was studied in male patients with lung Squam ous cell carcinoma. These patients were divided into two groups, depen ding on their tolerance for surgical intervention and pn the postopera tive course: (1) patients with an uneventful postoperative period and (2) patients with postoperative complications.-The genetic structure o f the combined sample at the loci studied did not differ from that of the control group consisting of healthy people (population central). G enotypic differences might manifest at the postoperative stage rather than at the onset of the disease, and determine the presence of postop erative complications. However, comparative analysis of the two groups of patients revealed their polar divergence in respect to phenotype a nd gene frequencies at certain loci. Moreover, the genotypic structure of patients in both groups differed from that in the combined sample and in the population control. In the group with postoperative complic ations, higher frequencies of the alleles GC1F, ACP1*A, and HP*2 were observed. By contrast, the group of patients with an uneventful posto perative period demonstrated prevalence of the alternative alleles of these loci: GC2, ACP1*B, and HP*1. The greatest difference in the dis tribution of informative allele frequencies was observed between the g roup of patients with postoperative complications and the control grou p. This is evidence that these groups significantly differ in their ge netic structure. Such divergence is largely determined by the polymorp hic multifunctional systems of serum proteins.