IN-VITRO SYNERGISTIC EFFECTS OF SOME NOVEL CU(II) COMPLEXES IN COMBINATION WITH EPIRUBICIN AND MITOMYCIN-C AGAINST HELA-S3 CERVICAL-CANCER CELL-LINE

Authors
GEROMICHALOS GD KATSOULOS GA HADJIKOSTAS CC KORTSARIS AH KYRIAKIDIS DA
Citation
Gd. Geromichalos et al., IN-VITRO SYNERGISTIC EFFECTS OF SOME NOVEL CU(II) COMPLEXES IN COMBINATION WITH EPIRUBICIN AND MITOMYCIN-C AGAINST HELA-S3 CERVICAL-CANCER CELL-LINE, Anti-cancer drugs, 7(4), 1996, pp. 469-475
Citations number
24
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Anti-cancer drugs → ACNP
ISSN journal
09594973
Volume
7
Issue
4
Year of publication
1996
Pages
469 - 475
Database
ISI
SICI code
0959-4973(1996)7:4<469:ISEOSN>2.0.ZU;2-M
Abstract
The in vitro predictive chemosensitivity of a HeLa-S3 human cervical c ancer cell line to a new series of Cu(ll) complexes as well as their c ombination with several chemotherapeutic drugs was determined. Antipro liferative activity was evaluated by the XTT assay, Among all tested d rugs, HeLa-S3 cells were especially sensitive to epirubicin (EPR) or m itomycin C (MMC) antitumor agents, The combination of EPR or MMC with the complexes resulted in a pronounced synergistic amplification of th eir antiproliferative effect, This marked synergism was observed in al l drug combinations.