THERAPEUTIC USES OF ASPIRIN IN RENAL DISEASES

Inhibition, by aspirin, of platelet aggregation, prostaglandin synthes is, smooth muscle cell proliferation, and thromboxane genesis has pote ntial therapeutic uses in renal diseases, Clinically, some benefit fro m aspirin has been shown in some forms of glomerulonephritis but not i n others, such as renovascular hypertension, pregnancy-induced hyperte nsion, and diabetic nephropathy, Experimentally, aspirin aided in amel ioration of cyclosporine toxicity and in preservation of explanted kid neys being prepared for transplantation. (C) 1996 by the National Kidn ey Foundation, Inc.