ACETAMINOPHEN ASPIRIN MIXTURES - EXPERIMENTAL-DATA/

The pertinent literature concerning the experimental induction of anal gesic nephropathy is reviewed, Based on the accumulated data from anim al experiments that induced a pathologic lesion resembling chronic ana lgesic nephropathy, of the limited number of analgesics tested, aspiri n seems to be the most nephrotoxic of the commonly available analgesic s, When aspirin is combined with other analgesics, the limited data av ailable suggest at least an additive nephrotoxic effect, if not a syne rgism. The histologic presentation of acute intoxication is substantia lly different from that following chronic ingestion. With improvements in pathologic analysis of experimental results, Mure studies may well provide more insight as to the significance, relative contribution, a nd risk of combination analgesic products in inducing experimental ana lgesic nephrotoxicity. (C) 1996 by the National Kidney Foundation, Inc .