STEREOCHEMICAL STUDY OF 7-ARYL-1,7,8,8A-TETRAHYDRO-3(2H)INDOLIZINONESBY H-1 AND C-13 NMR

Stereochemistry of 7-aryl-1,7,8,8a-tetrahydro-3(2H)-indolizinones was studied by H-1 and C-13 NMR. Complete assignment of H-1 NMR signals an d analysis of H-1-H-1 coupling constants were performed using the iter ative PANIC program, values of (3)J(6,7), (3)J(7,8endo), and (4)J(5,7) allow one to unambiguously identify the corresponding exo- and endo-s tereoisomer. For stereoisomers with exo-orientation of H(7), complete assignment of C-13 NMR signals was performed on the basis of analysis of the C-13-H-1 coupling constants using two-dimensional heteronuclear shift-correlating spectroscopy.