PREMATURE CENTROMERE DIVISION IN 3 UNRELATED FAMILIES

We describe three unrelated families with an increased frequency of ce lls with premature centromere division (PCD) in all of the chromosomes . There were eight phenotypically normal individuals with PCD in these families. Familial PCD phenomenon is different from the described PCD of X chromosome and of the cells of patients with Roberts syndrome. I n this study, we discussed our findings in different medium and time a nd with/without colcemid in cases referred with spontaneous abortions and in the father of a child who had chromosomal abnormality. In our f amilies, this anomaly was transmitted in a way compatible with autosom al dominant inheritance.