In elderly subjects (above 65 years), cardio- and cerebrovascular dise
ases are known to contribute to the death rate. Serum lipoprotein(a) =
Lp(a), a low density lipoprotein, is involved in the atherogenic proc
esses, as confirmed by several clinical trials. We evaluated serum Lp(
a) levels in a group of centenarians (15 females and 7 males, mean age
102.81 +/- 2.5 years) compared to 25 healthy control subjects (10 mal
es and 15 females, mean age 51.12 +/- 15.34 years). In all subjects Lp
(a) serum levels were determined by ELISA-method (EIA mod. 2550 reader
). Statistical analysis of the results was performed by using the Stud
ent's t test. in centenarians the mean Lp(a) level increased (39.6 +/-
23.53 mg/dl) compared to that of the control group (16.78 +/- 16.24 m
g/dl) (p < 0.005). The elevated Lp(a) values observed in centenarians
may be attributed to the presence of low molecular weight lipoprotein
isoforms which are known to be associated with cardio-cerebrovascular
risk. Therefore, it seems that elevated Lp(a) levels alone are not ris
k factors for the onset of acute vascular accidents and do not influen
ce longevity.