The total hip replacement (THR) survival potential is linked to the ma
terial, to surgical technique and to patient's characteristics. Cement
ed and cementless systems exist in a wide variety of shapes, sizes, co
nfigurations, materials and surface treatments. Aseptic loosening rema
in the principal mechanism of prosthetic failure and the choice of rig
ht matching for each prosthesis-patient is the main issue to obtain a
very good long-term implant fixation. Cement fixation is always solidl
y achieved but it can break down under mechanical and biological press
ure. Stability with cementless fixation must be created by the initial
bone response to the implant. Clinical studies and long-term results
with THR showed that in patients with age between 60 and 70 years, it
is important to analyze several parameters (bone quality and morpholog
y, life-limiting diseases and levels of activity) to make the appropri
ate selection of components and type of fixation.