Vg. Nicoletti et al., AGE-RELATED-CHANGES OF MITOCHONDRIAL CYTOCHROME-C-OXIDASE AND F-0-F-1-ATP SYNTHASE SUBUNIT CONTENTS IN RAT CEREBRAL-CORTEX, Archives of gerontology and geriatrics, 1996, pp. 509-513
The levels of subunits I, II/III, and IV of cytochrome c oxidase and o
f subunits alpha, beta and gamma of F0F1-ATP synthase in inner mitocho
ndrial membrane proteins purified from cerebral cortex of rat at 2, 6,
12, 18, 24, 26 months of age were analyzed by Western blot. Age-relat
ed changes in the content of subunits, encoded either in mitochondrial
or nuclear DNA, were observed.