A combination of disease related and iatrogenic Factors predispose onc
ologic patients to opportunistic infections. Aggressive treatments inc
luding high-dose chemotherapeutic regimens or bone marrow transplantat
ion produce a patient population that is especially susceptible to inf
ections, and a shift of the usual spectrum of pathogens, Patterns of o
ccurrence of infections caused by opportunistic bacteria, fungi, virus
es, and rarely protozoa, as well as therapeutic anal prophylactic stra
tegies are discussed.