We write an O(d, d)-covariant Wheeler-De Witt equation in the (d(2) 1)-dimensional minisuperspace of low-energy cosmological string backgr
ounds. We discuss explicit examples of transitions between two duality
-related cosmological phases, and we find a finite quantum transition
probability even when the two phases are classically separated by a cu
rvature singularity. This quantum approach is completely free from ope
rator ordering ambiguities as a consequence of the duality symmetries
of the string effective action.